Pathology of the Developing Mouse

Pathology of the Developing Mouse provides, insofar as feasible, a comprehensive reference on the design, analysis, and interpretation of abnormal findings in developing mice before and shortly after birth. This book is intended not only as a "how to do" manual for developmental pathology experimentation in mice but, more importantly, as a "how to interpret" resource for pathologists and other biomedical scientists encountering the challenge of defining the significance of distorted features in murine development.

The topics covered in this volume encompass a full range of subjects encountered when building and wielding a developmental pathology tool kit:

• Baseline anatomic and physiologic traits of developing mice
• Principles of good experimental design and statistical analysis for mouse developmental pathology studies
• Procedures for anatomic pathology examinations, to evaluate structural changes at the macroscopic (gross), microscopic (cells and tissues), and ultrastructural (subcellular) levels, using conventional autopsy-based or novel non-invasive imaging techniques
• Methods for clinical pathology testing, to assess the biochemical and cellular composition of tissues and fluids
• Options and protocols for in situ molecular pathology analysis, to undertake site-specific explorations of the various mechanisms responsible for producing adverse findings (i.e., "lesions") during development
• Well-referenced and illustrated guides to the interpretation of anatomic pathology and clinical pathology changes in the animal (embryos, fetuses, neonates, and juveniles) and its support system (placenta)