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Pathology of the Developing Mouse
A Systematic Approach
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Summary
The book covers a comprehensive range of topics: baseline anatomical and physiological traits of developing mice; principles of experimental design and statistical analysis; methods for anatomic pathology at macroscopic, microscopic, and ultrastructural levels using both traditional and novel imaging techniques; clinical pathology testing; in situ molecular pathology protocols; and thorough guides to interpreting pathological changes in embryos, fetuses, neonates, juvenile mice, and the placenta.
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Format: Paperback / softback
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Book Hero Magic created this recommendation. While it's new and still learning, it may not be perfect - your feedback is welcome! IS THIS YOUR NEXT READ?
This book is ideal for biomedical scientists, pathologists, and researchers specialising in developmental biology and mouse models, particularly those involved in pathology and experimental design related to developmental abnormalities.
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See moreThis book is the first publication to provide comprehensive guidance regarding the identification, characterization, and interpretation of mouse developmental defects. It emphasizes the interpretation of abnormal phenotypes and provides detailed protocols for appropriately processing mouse embryos, fetuses, neonates, juveniles, and placentas. A
Book Hero Magic formatted this description to make it easier to read. While it's new and
still learning, it may not be perfect - your
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Description
Pathology of the Developing Mouse provides, insofar as feasible, a comprehensive reference on the design, analysis, and interpretation of abnormal findings in developing mice before and shortly after birth. This book is intended not only as a "how to do" manual for developmental pathology experimentation in mice but, more importantly, as a "how to interpret" resource for pathologists and other biomedical scientists encountering the challenge of defining the significance of distorted features in murine development.
The topics covered in this volume encompass a full range of subjects encountered when building and wielding a developmental pathology tool kit:
- Baseline anatomic and physiologic traits of developing mice
- Principles of good experimental design and statistical analysis for mouse developmental pathology studies
- Procedures for anatomic pathology examinations, to evaluate structural changes at the macroscopic (gross), microscopic (cells and tissues), and ultrastructural (subcellular) levels, using conventional autopsy-based or novel non-invasive imaging techniques
- Methods for clinical pathology testing, to assess the biochemical and cellular composition of tissues and fluids
- Options and protocols for in situ molecular pathology analysis, to undertake site-specific explorations of the various mechanisms responsible for producing adverse findings (i.e., "lesions") during development
- Well-referenced and illustrated guides to the interpretation of anatomic pathology and clinical pathology changes in the animal (embryos, fetuses, neonates, and juveniles) and its support system (placenta)
Book Details
INFORMATION
ISBN: 9780367575779
Publisher: Taylor & Francis Ltd
Format: Paperback / softback
Date Published: 30 June 2020
Country: United Kingdom
Imprint: CRC Press
Contributors:
- Edited by Brad Bolon
Audience: Professional and scholarly
DIMENSIONS
Width: 178.0mm
Height: 254.0mm
Weight: 830g
Pages: 446
Collections
About the Author
Brad Bolon, DVM, MS, PhD, is a Diplomate of both the American College of Veterinary Pathologists (DACVP) and the American Board of Toxicology (DABT) as well as a Fellow of both the Academy of Toxicological Sciences (FATS) and the International Academy of Toxicologic Pathology (FIATP). He is currently an associate professor in the Department of Veterinary Biosciences, College of Veterinary Medicine and also the associate director of the Comparative Pathology and Mouse Phenotyping Shared Resource, Comprehensive Cancer Center at the Columbus campus of The Ohio State University (OSU). His main professional interests are the pathology of genetically engineered mice (especially embryos, fetuses, neonates, and placentas) and toxicologic neuropathology.
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