Curved Air
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Curved Air
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See moreCurved Air chronicles the story of sickle cell anemia from its ancient origins in Sub-Saharan Africa to its central role in the development of human genome editing. For decades, patients, many of whom are Black, were denied lifesaving care. But hope has arrived in the form of a revolutionary gene-editing therapy: CRISPR.
How sickle cell anaemia led the quest to edit the human genome while patients endured decades of racial discrimination and medical neglect.
In December 1904, Walter Clement Noel, a dental student from Grenada, was admitted to a Chicago hospital with fever, jaundiced eyes, and ulcers covering his legs. When doctors examined his blood under a microscope, they were puzzled by his sickle-shaped cells. His case became enshrined in the annals of medicine as the first report of sickle cell anaemia, a fatal disease that starves the body's organs of oxygen, causing excruciating pain.
In Curved Air, Kevin Davies chronicles the story of sickle cell anaemia from its ancient origins in Sub-Saharan Africa to its central role in the development of human genome editing, revealing how one of the world's most famous genetic diseases became its most neglected. Sickle cell anaemia was the first disease to be attributed to a molecular anomaly and the first to be diagnosed prenatally with DNA testing. Yet for decades, patients, many of whom are Black, were denied lifesaving care by health providers quick to dismiss them as drug seekers. It was only after a group of researchers in the US and Europe partnered with biotech companies, physicians, and their patients that hope arrived in the form of a revolutionary gene-editing therapy: CRISPR.
A story of failure and breakthroughs, heartbreak and hope, Curved Air is a celebration of the scientists, physicians, and patients who are finally catching a glimpse of the cure they've waited generations to see.
Book Details
INFORMATION
ISBN: 9780674293960
Publisher: Harvard University Press
Format: Hardback
Date Published: 08 September 2026
Country: United States
Imprint: Harvard University Press
Illustration: 16 color photos, 5 illus.
Audience: Tertiary education, Professional and scholarly
DIMENSIONS
Spine width: 25.0mm
Width: 156.0mm
Height: 235.0mm
Weight: 711g
Pages: 352
About the Author
Kevin Davies is Executive Editor of The CRISPR Journal and founding editor of Nature Genetics. A recipient of the Guggenheim Fellowship, he is the author or coauthor of Editing Humanity, Cracking the Genome, The $1,000 Genome, and DNA.
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