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Human Drug Metabolism
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Human Drug Metabolism
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Book Hero Magic formatted this description to make it easier to read. While it's new and
still learning, it may not be perfect - your
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Description
Provides a timely update to a key textbook on human drug metabolism.
The third edition of this comprehensive book covers basic concepts of teaching drug metabolism, beginning with extreme clinical consequences to systems, mechanisms, and toxicity. It provides an invaluable introduction to the core areas of pharmacology and examines recent progress and advances in this fast-moving field and its clinical impact.
Human Drug Metabolism, 3rd Edition begins by addressing basic concepts such as clearance and bioavailability, and explores the evolution of biotransformation and how drugs integrate into this carefully managed biological environment. This new edition offers more information on the functioning of cytochrome P450s and their modulation at the sub-cellular level.
The book introduces helpful concepts for those navigating the relationship between pharmacology and physiology, as well as the inhibition of biotransformational activity. It covers recent advances in knowledge of other metabolising systems, including glucuronidation and sulphation, and reviews the main drug transporters. Themes from the previous edition are further developed, attempting to chart the progress of personalised medicine from concepts to practical inclusion in routine therapeutics.
The final chapter focuses on understanding how and why drugs may cause injuries, both in predictable and unpredictable ways. Appendix A provides practical approaches used in drug metabolism research and drug discovery. Appendix B outlines the metabolism of various drugs of abuse, while Appendix C advises on formal examination preparation and Appendix D lists substrates, inducers, and inhibitors of the major human cytochrome P450s.
- Fully updated to reflect advances in the scientific field of drug metabolism and its clinical impact.
- Reflects refinements in the author's teaching method, particularly in aiding students' understanding of biological systems and their operations.
- Illustrates the growing relationship between drug metabolism and personalised medicine.
- Includes recent developments in drug discovery, genomics, and stem cell technologies.
Human Drug Metabolism, 3rd Edition is an excellent resource for advanced undergraduate and graduate students in molecular biology, biochemistry, pharmacology, pharmacy, and toxicology. It will also attract professionals seeking an introduction to this field or wishing to deepen their understanding of these bench-to-bedside topics to apply them in practice.
Book Details
INFORMATION
ISBN: 9781119458562
Publisher: John Wiley and Sons Ltd
Format: Paperback / softback
Date Published: 10 February 2020
Country: United Kingdom
Imprint: Wiley-Blackwell
Edition: 3rd edition
Audience: Professional and scholarly
DIMENSIONS
Spine width: 28.0mm
Width: 147.0mm
Height: 224.0mm
Weight: 975g
Pages: 688
About the Author
Michael D. Coleman, Presently Professor of Toxicology at Aston University. During his career, Dr. Coleman has studied and worked at Liverpool University, The Liverpool School of Tropical Medicine, Walter Reed Army Institute of Research in Washington D.C. and latterly Aston University. His substantial and original contribution to knowledge of the biochemical pharmacology and toxicology of antiparasitic drugs has been acknowledged in the award of the degree of Doctor of Science in 2005.
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