Genetics and Genomics in Medicine

The second edition of this textbook, written for undergraduate students, graduate students, and medical researchers, Genetics and Genomics in Medicine, explains the science behind the uses of genetics and genomics in medicine today, and how it is being applied.

Maintaining the features that made the first edition so popular, this second edition has been thoroughly updated in line with the latest developments in the field. DNA technologies are explained, with emphasis on the modern techniques that are revolutionising the use of genetic information in medicine and indicating the role of genetics in common diseases. Epigenetics and non-coding RNA are covered in-depth as are genetic approaches to treatment and prevention, including pharmacogenomics, genetic testing, and personalised medicine. A dedicated chapter charts the latest insights into the molecular basis of cancers, cancer genomics, and novel approaches to cancer detection. Coverage of genetic testing at the level of genes, chromosomes, and genomes has been significantly expanded and updated. Extra prominence has been given to additional genomic analyses, ethical aspects, and novel therapeutic approaches. Various case studies illustrate selected clinical applications.

Key Features

• Comprehensive and integrated account of how genetics and genomics affect the entire spectrum of human health and disease
• Exquisite artwork illuminates the key concepts and mechanisms
• Summary points at the end of each chapter help to consolidate learning
• An abundance of further reading in each chapter provides direction for further study
• Inclusive online question bank to test understanding
• Standard boxes summarise certain key principles in genetics
• Clinical boxes summarise selected case studies, pathogenesis mechanisms, or novel therapies for selected diseases

This book is equally suited for newcomers to the field, as well as for engineers and scientists who have basic knowledge in this field but are interested in obtaining more information about specific future applications.