{"product_id":"human-drug-metabolism-by-michael-d-coleman-9781119458562","title":"Human Drug Metabolism","description":"\u003cdiv class=\"book-description\"\u003e\n\u003cp\u003e\u003cstrong\u003eProvides a timely update to a key textbook on human drug metabolism.\u003c\/strong\u003e\u003c\/p\u003e\n\n\u003cp\u003eThe third edition of this comprehensive book covers basic concepts of teaching drug metabolism, beginning with extreme clinical consequences to systems, mechanisms, and toxicity. It provides an invaluable introduction to the core areas of pharmacology and examines recent progress and advances in this fast-moving field and its clinical impact.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eHuman Drug Metabolism, 3rd Edition\u003c\/em\u003e begins by addressing basic concepts such as clearance and bioavailability, and explores the evolution of biotransformation and how drugs integrate into this carefully managed biological environment. This new edition offers more information on the functioning of cytochrome P450s and their modulation at the sub-cellular level.\u003c\/p\u003e\n\n\u003cp\u003eThe book introduces helpful concepts for those navigating the relationship between pharmacology and physiology, as well as the inhibition of biotransformational activity. It covers recent advances in knowledge of other metabolising systems, including glucuronidation and sulphation, and reviews the main drug transporters. Themes from the previous edition are further developed, attempting to chart the progress of personalised medicine from concepts to practical inclusion in routine therapeutics.\u003c\/p\u003e\n\n\u003cp\u003eThe final chapter focuses on understanding how and why drugs may cause injuries, both in predictable and unpredictable ways. Appendix A provides practical approaches used in drug metabolism research and drug discovery. Appendix B outlines the metabolism of various drugs of abuse, while Appendix C advises on formal examination preparation and Appendix D lists substrates, inducers, and inhibitors of the major human cytochrome P450s.\u003c\/p\u003e\n\n\u003cul\u003e\n\u003cli\u003eFully updated to reflect advances in the scientific field of drug metabolism and its clinical impact.\u003c\/li\u003e\n\u003cli\u003eReflects refinements in the author's teaching method, particularly in aiding students' understanding of biological systems and their operations.\u003c\/li\u003e\n\u003cli\u003eIllustrates the growing relationship between drug metabolism and personalised medicine.\u003c\/li\u003e\n\u003cli\u003eIncludes recent developments in drug discovery, genomics, and stem cell technologies.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003e\u003cem\u003eHuman Drug Metabolism, 3rd Edition\u003c\/em\u003e is an excellent resource for advanced undergraduate and graduate students in molecular biology, biochemistry, pharmacology, pharmacy, and toxicology. It will also attract professionals seeking an introduction to this field or wishing to deepen their understanding of these bench-to-bedside topics to apply them in practice.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Unknown","offers":[{"title":"Default Title","offer_id":46854597902572,"sku":"9781119458562","price":184.99,"currency_code":"NZD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0705\/7784\/8556\/files\/bdaf023a8e535ad5fe70a46d29bde86c.jpg?v=1759267869","url":"https:\/\/bookhero.co.nz\/products\/human-drug-metabolism-by-michael-d-coleman-9781119458562","provider":"Book Hero","version":"1.0","type":"link"}