{"title":"Series: Wiley Series in Drug Discovery and Development","description":null,"products":[{"product_id":"drug-transporters-9781119737551","title":"Drug Transporters","description":"\u003cdiv class=\"book-description\"\u003e\n\u003cp\u003e\u003cb\u003eDRUG TRANSPORTERS\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003e\u003cb\u003eDrug transporter fundamentals and relevant principles and techniques, featuring new and expanded chapters\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003e\u003ci\u003eDrug Transporters: Molecular Characterization and Role in Drug Disposition\u003c\/i\u003e provides an in-depth analysis of the conceptual evolution and technical development for studying drug transporters. Contributions by an international panel of leading researchers address advances in transporters as drug targets, transporters in pharmacotherapy, the impact of transporters on drug efficacy and safety, the development of sophisticated model systems and sensitive assay methods, and more. Divided into two parts, the book first provides a thorough overview of relevant drug transporters before detailing the principles of drug transport and associated techniques.\u003c\/p\u003e\n\n\u003cp\u003eThe updated and expanded third edition includes new chapters on in vitro-in vivo scale-up of drug transport activities, the ontogeny of drug transporters, the application of physiologically-based pharmacokinetic and pharmacodynamic modelling, and the use of transporters as therapeutic targets for diseases.\u003c\/p\u003e\n\n\u003cul\u003e\n    \u003cli\u003eReflects the current state of the field and offers perspectives on future directions\u003c\/li\u003e\n    \u003cli\u003eCovers basic knowledge, clinical outcomes, and emerging discoveries in transporter science\u003c\/li\u003e\n    \u003cli\u003eProvides up-to-date information on drug transporter families, mechanisms, and clinical implications\u003c\/li\u003e\n    \u003cli\u003eIncludes extensive references and numerous figures and tables throughout\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eUnderstandable for novices while offering sufficient depth for more experienced researchers, \u003ci\u003eDrug Transporters: Molecular Characterization and Role in Drug Disposition, Third Edition\u003c\/i\u003e is an excellent textbook for pharmacological or physiological science courses in drug\/membrane transport, and an invaluable reference for academic or industrial scientists working in the transporter field and related areas of drug metabolism, pharmacokinetics, and pharmacodynamics.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Unknown","offers":[{"title":"Default Title","offer_id":46854462832876,"sku":"9781119737551","price":514.99,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0705\/7784\/8556\/files\/ea04d8eae922c1bcaee1b77307d404bc.jpg?v=1759269816"},{"product_id":"hydrogen-sulfide-9781119799870","title":"Hydrogen Sulfide","description":"\u003cdiv class=\"book-description\"\u003e\n\u003cp\u003e\u003cem\u003eHydrogen Sulfide\u003c\/em\u003e covers H\u003csub\u003e2\u003c\/sub\u003eS interactions, methods of detection and delivery in biological environments, and a wide range of applications.\u003c\/p\u003e\n\n\u003cp\u003eResearch on hydrogen sulfide (H\u003csub\u003e2\u003c\/sub\u003eS) spans diverse disciplines including chemistry, biology, and physiology. In recent years, new materials and approaches have been developed to deliver H\u003csub\u003e2\u003c\/sub\u003eS and related reactive sulfur species in various clinical contexts. Although many biological pathways involving H\u003csub\u003e2\u003c\/sub\u003eS are complex, all are governed by fundamental chemical interactions between reactive sulfur species and other molecular entities.\u003c\/p\u003e\n\n\u003cp\u003e\u003cem\u003eHydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies\u003c\/em\u003e provides the foundation required for understanding the fundamental chemical biology of H\u003csub\u003e2\u003c\/sub\u003eS while highlighting the compound’s therapeutic potential and medicinal applications. This book covers key aspects of H\u003csub\u003e2\u003c\/sub\u003eS chemical biology, including the fundamental chemistry of reactive sulfur species; the measurement, detection, and delivery of H\u003csub\u003e2\u003c\/sub\u003eS in biological environments; and the therapeutic and medicinal uses of exogenous H\u003csub\u003e2\u003c\/sub\u003eS delivery in various pharmacologically relevant systems. Throughout the text, editor Michael Pluth and chapter contributors discuss the opportunities and future of the multidisciplinary field.\u003c\/p\u003e\n\n\u003cul\u003e\n\u003cli\u003eProvides approaches for delivering H\u003csub\u003e2\u003c\/sub\u003eS with relevance to biological and therapeutic applications.\u003c\/li\u003e\n\u003cli\u003eDescribes complex interactions of H\u003csub\u003e2\u003c\/sub\u003eS with bioinorganic complexes and reactive sulfur, nitrogen, and oxygen species.\u003c\/li\u003e\n\u003cli\u003eSummarizes advances in available tools to detect, measure, and modulate H\u003csub\u003e2\u003c\/sub\u003eS levels in biological environments, such as real-time methods for H\u003csub\u003e2\u003c\/sub\u003eS fluorescence imaging in live cell and animal systems.\u003c\/li\u003e\n\u003cli\u003eHelps readers understand known systems and make connections to new and undiscovered pathways and mechanisms of action.\u003c\/li\u003e\n\u003cli\u003eIncludes in-depth case studies of different systems in which H\u003csub\u003e2\u003c\/sub\u003eS plays an important role.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003e\u003cem\u003eHydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies\u003c\/em\u003e is an important source of current knowledge for researchers, academics, graduate students, and industrial scientists in the fields of redox biology, hydrogen sulfide research, and medicinal chemistry of small biological molecules.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Unknown","offers":[{"title":"Default Title","offer_id":46854599835884,"sku":"9781119799870","price":476.99,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0705\/7784\/8556\/files\/8c5964eebffd0f6d2cb8a1f49099bd15.jpg?v=1759267833"},{"product_id":"nucleic-acids-in-medicinal-chemistry-and-chemical-biology-9781119692744","title":"Nucleic Acids in Medicinal Chemistry and Chemical Biology","description":"\u003cdiv class=\"book-description\"\u003e\n\u003cp\u003e\u003cb\u003eAn up-to-date and comprehensive exploration of nucleic acid medicinal chemistry and its applications\u003c\/b\u003e\u003c\/p\u003e\n\n\u003cp\u003eIn \u003ci\u003eNucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications\u003c\/i\u003e, a team of distinguished researchers delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasises the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers.\u003c\/p\u003e\n\n\u003cp\u003eThe authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the reader a wealth of new drug discovery opportunities emerging in this dynamic field.\u003c\/p\u003e\n\n\u003cp\u003eReaders will also find:\u003c\/p\u003e\n\n\u003cul\u003e\n    \u003cli\u003eA thorough introduction to the basic terminology and knowledge of the field of nucleic acid medicinal chemistry\u003c\/li\u003e\n    \u003cli\u003eComprehensive explorations of the methods used to determine the development of nucleic acid drugs\u003c\/li\u003e\n    \u003cli\u003ePractical discussions of new technologies, like CRISPR, nanotechnology-based delivery systems, synthetic biology, and DNA-encoded chemical libraries\u003c\/li\u003e\n    \u003cli\u003eIn-depth examinations of the latest, cutting-edge developments in nucleic acid medicinal chemistry\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003ePerfect for medicinal and nucleic acid chemists, \u003ci\u003eNucleic Acids in Medicinal Chemistry and Chemical Biology\u003c\/i\u003e will also earn a place in the libraries of biochemists, chemical biologists, and pharmaceutical researchers.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"Unknown","offers":[{"title":"Default Title","offer_id":46854714720492,"sku":"9781119692744","price":476.99,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0705\/7784\/8556\/files\/d84178b4b534015ff6ae095d4ef01bb5.jpg?v=1759265983"}],"url":"https:\/\/bookhero.co.nz\/collections\/series-wiley-series-in-drug-discovery-and-development.oembed","provider":"Book Hero","version":"1.0","type":"link"}